GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs10935120 | 1 | rs7611828 | chr3:134250325 | CEP63 | chr3:134204575-134293852:+ | 0.23 | 3.93 | 0.000102 | Height |
| BLCA | cis | rs6951245 | 1 | rs76129108 | chr7:1089159 | ZFAND2A | chr7:1192544-1199855:- | -0.38 | -4.53 | 8.04E-6 | C-reactive protein levels or total cholesterol levels (pleiotropy) |
| BLCA | cis | rs7615952 | 1 | rs7615952 | chr3:125649403 | ALG1L | chr3:125648118-125655882:- | 0.37 | 6.56 | 1.77E-10 | Blood pressure (smoking interaction) |
| BLCA | cis | rs7615952 | 1 | rs7615952 | chr3:125649403 | LOC100125556 | chr3:125635444-125648865:+ | -0.35 | -5.31 | 1.9E-7 | Blood pressure (smoking interaction) |
| BLCA | cis | rs7615952 | 1 | rs7616044 | chr3:125649354 | ALG1L | chr3:125648118-125655882:- | -0.38 | -6.67 | 8.89E-11 | Blood pressure (smoking interaction) |
| BLCA | cis | rs7615952 | 1 | rs7616044 | chr3:125649354 | LOC100125556 | chr3:125635444-125648865:+ | 0.33 | 5.06 | 6.37E-7 | Blood pressure (smoking interaction) |
| BLCA | cis | rs9815354 | 1 | rs7616844 | chr3:41874343 | ULK4 | chr3:41288091-42003660:- | 0.64 | 9.91 | 9.53E-21 | Diastolic blood pressure |
| BLCA | cis | rs9815354 | 1 | rs7617397 | chr3:41959037 | ULK4 | chr3:41288091-42003660:- | -0.63 | -9.71 | 4.41E-20 | Diastolic blood pressure |
| BLCA | cis | rs344081 | 1 | rs7617912 | chr3:156576412 | LEKR1 | chr3:156544076-156763918:+ | -0.46 | -6.34 | 6.48E-10 | Bone mineral density |
| BLCA | cis | rs10935120 | 1 | rs7619451 | chr3:134233238 | ANAPC13 | chr3:134196547-134204865:- | 0.5 | 7.63 | 1.86E-13 | Height |
| BLCA | cis | rs344081 | 1 | rs7620458 | chr3:156576850 | LEKR1 | chr3:156544076-156763918:+ | -0.46 | -6.36 | 5.8E-10 | Bone mineral density |
| BLCA | cis | rs6951245 | 1 | rs76214082 | chr7:1102097 | ZFAND2A | chr7:1192544-1199855:- | -0.38 | -4.41 | 1.36E-5 | C-reactive protein levels or total cholesterol levels (pleiotropy) |
| BLCA | cis | rs9815354 | 1 | rs7622259 | chr3:41881351 | ULK4 | chr3:41288091-42003660:- | 0.64 | 9.91 | 9.53E-21 | Diastolic blood pressure |
| BLCA | cis | rs9815354 | 1 | rs7624372 | chr3:41881107 | ULK4 | chr3:41288091-42003660:- | 0.64 | 9.91 | 9.53E-21 | Diastolic blood pressure |
| BLCA | cis | rs763014 | 1 | rs763014 | chr16:675680 | WFIKKN1 | chr16:679239-684116:+ | 0.28 | 5.27 | 2.23E-7 | Height |